on Gut-Associated Lymphoid Tissue in Rabbits Dependence of Antibody Somatic Diversification
نویسندگان
چکیده
منابع مشابه
Intestinal microflora and diversification of the rabbit antibody repertoire.
The rabbit establishes its primary Ab repertoire by somatically diversifying an initial repertoire that is limited by restricted VH gene segment usage during VDJ gene rearrangement. Somatic diversification occurs in gut-associated lymphoid tissue (GALT), and by about 1-2 mo of age nearly all Ig VDJ genes are somatically diversified. In other species that are known to establish their primary Ab ...
متن کاملRole of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire.
Intestinal bacteria are required for development of gut-associated lymphoid tissues (GALT), which mediate a variety of host immune functions, such as mucosal immunity and oral tolerance. In rabbits, the intestinal microflora are also required for developing the preimmune Ab repertoire by promoting somatic diversification of Ig genes in B cells that have migrated to GALT. We studied the mechanis...
متن کاملComparative immunohistochemistry of Gut-associated lymphoid tissue (GALT) of, Huso huso in two warm and cold seasons
Abstract The main objective of recent study was comparative immunohistochemistry of Gut-associated lymphoid tissue (GALT) of, Huso huso in two warm and cold seasons. Ten specimens were collected from sturgeon breeding centers and after anesthesia, biometric was taken on them. 0.5 centimeter samples of primary, middle and end of intestine were removed and immediately were placed in Bouin soluti...
متن کاملAntigen-induced somatic diversification of rabbit IgH genes: gene conversion and point mutation.
During T cell-dependent immune responses in mouse and human, Ig genes diversify by somatic hypermutation within germinal centers. Rabbits, in addition to using somatic hypermutation to diversify their IgH genes, use a somatic gene conversion-like mechanism, which involves homologous recombination between upstream VH gene segments and the rearranged VDJ genes. Somatic gene conversion and somatic...
متن کاملGene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.
The young rabbit appendix and the chicken bursa of Fabricius are primary lymphoid organs where the B cell Ab repertoire develops in germinal centers (GCs) mainly by a gene conversion-like process. In human and mouse, V-gene diversification by somatic hypermutation in GCs of secondary lymphoid organs leads to affinity maturation. We asked whether gene conversion, somatic hypermutation, or both o...
متن کامل